Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
Identifieur interne : 001526 ( Main/Exploration ); précédent : 001525; suivant : 001527Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
Auteurs : Yang Yang [États-Unis] ; Chang Liu [États-Unis] ; Lanying Du [États-Unis] ; Shibo Jiang [République populaire de Chine] ; Zhengli Shi [République populaire de Chine] ; Ralph S. Baric [États-Unis] ; Fang Li [États-Unis]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Humains, Infections à coronavirus (génétique), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Lignée cellulaire, Mutation, Protéines virales structurales (génétique), Récepteurs viraux (génétique).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4, Infections à coronavirus, Protéines virales structurales, Récepteurs viraux.
- métabolisme : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4.
- virologie : Chiroptera, Infections à coronavirus.
- transmission : Animaux, Humains, Infections à coronavirus, Lignée cellulaire, Mutation.
English descriptors
- KwdEn :
- Animals, Cell Line, Chiroptera (virology), Coronavirus Infections (genetics), Coronavirus Infections (transmission), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (metabolism), Mutation, Receptors, Virus (genetics), Viral Structural Proteins (genetics).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, Receptors, Virus, Viral Structural Proteins.
- genetics : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- virology : Chiroptera, Coronavirus Infections.
- Animals, Cell Line, Humans, Mutation.
Abstract
To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explaining why MERS-CoV infects human cells. These mutations therefore played critical roles in the bat-to-human transmission of MERS-CoV, either directly or through intermediate hosts.
DOI: 10.1128/JVI.01279-15
PubMed: 26063432
Affiliations:
- République populaire de Chine, États-Unis
- Caroline du Nord, Hubei, Minnesota, État de New York
- Wuhan
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Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explaining why MERS-CoV infects human cells. These mutations therefore played critical roles in the bat-to-human transmission of MERS-CoV, either directly or through intermediate hosts. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Hubei</li><li>Minnesota</li><li>État de New York</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name></region><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><name sortKey="Liu, Chang" sort="Liu, Chang" uniqKey="Liu C" first="Chang" last="Liu">Chang Liu</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name></noRegion><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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